LncRNA TATDN1 contributes to the cisplatin resistance of non-small cell lung cancer through TATDN1/miR-451/TRIM66 axis.

CONCLUSIONS: TATDN1 enhanced the DDP-tolerance of NSCLC cells by upregulating TRIM66 expression via sponging miR-451, hinting a novel regulatory pathway of chemoresistance in DDP-tolerant NSCLC cells and providing a potential therapeutic target for NSCLC patients with DDP-reistance.
PMID: 30481109 [PubMed - as supplied by publisher]

Source: Cancer Biology and Therapy - November 27, 2018 Category: Cancer & Oncology Authors: Wang L, Shang X, Feng Q Tags: Cancer Biol Ther Source Type: research