High-contrast imaging for cancer therapy with protons

(Helmholtz-Zentrum Dresden-Rossendorf) Medical physicist Dr. Aswin Hoffmann and his team from the Institute of Radiooncology -- OncoRay at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) are the first researchers worldwide to combine magnetic resonance imaging with a proton beam, thus demonstrating that in principle, this commonly used imaging method can indeed work with particle beam cancer treatments. This opens up new opportunities for targeted, healthy tissue-sparing cancer therapy. The researchers published their results in the journal Physics in Medicine and Biology.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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AbstractPurpose of reviewThe emerging complexity of cardiac toxicity caused by cancer therapies has created demand for more advanced non-invasive methods to better evaluate cardiac structure, function, and myocardial tissue characteristics. Cardiac magnetic resonance imaging meets these needs without exposure to ionizing radiation, and with superior spatial resolution.Recent findingsSpecial applications of cardiac magnetic resonance (CMR) to assess for cancer therapy –induced cardiac toxicity include the detection of subclinical LV dysfunction through novel methods of measuring myocardial strain, detection of microci...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Conclusions Several model systems are now available to characterize the MSC-tumour interplay in the TME. These offer early promise in establishing robust preclinical platforms for the identification of crucial molecular pathways and for the assessment of clinical efficacy of novel drugs to inhibit cancer development and progression. However, selection of the right model for a given study should be shaped on the purpose, and should also consider fixed biological, biochemical, and biophysical parameters according to the specific tumour type. Finally, in order to get reliable and useful results to be translated to the clinic...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Mark E. Gray1,2*, James Meehan2,3, Paul Sullivan4, Jamie R. K. Marland4, Stephen N. Greenhalgh1, Rachael Gregson1, Richard Eddie Clutton1, Carol Ward2, Chris Cousens5, David J. Griffiths5, Alan Murray4 and David Argyle1 1The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom 2Cancer Research UK Edinburgh Centre and Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 3School of Engineering and Physical Sciences, Institute of Sensors, Signals and Systems, Heriot-Watt Univer...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study protocol was approved by the Institutional Review Board of the hospital. Data Collection Demographic and clinical data were retrieved from medical records in the hospital’s centralized database. These data included the age at diagnosis, International Federation of Obstetrics and Gynecologic (FIGO) stage, tumor histology and grade, type of surgery, and types and cycles of chemotherapy. Disease staging was based on the 2014 FIGO staging system. Optimal debulking surgery was defined as residual tumors with maximal diameters less than 1 cm; the others were defined as suboptimal debulking surgery. Disease rec...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: 15 August 2019Source: Chemical Engineering Journal, Volume 370Author(s): Fan Wu, Ming Zhang, Xiaohong Chu, Qicheng Zhang, Yutian Su, Baohong Sun, Tingyu Lu, Ninglin Zhou, Jun Zhang, Jianxiu Wang, Xinyao YiAbstractChemotherapy resistance hinders the successful clinical cancer therapy, because of the low sensitivity of drugs to resistant cancer cells. In resistant cancer cells, the mutant p53 possesses anti-apoptosis capability to tolerate chemotherapeutic drugs such as doxorubicin (DOX). Phenethyl isothiocyanate (PEITC) derived from cruciferous vegetables can deplete intracellular mutant p53. In this work,...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ00263D, PaperDong Xu, Muhammad A Tahir, Liwu Zhang, Christian G. Sch äfer Here we report a straight forward synthetic procedure for the preparation of metal-containing polymer microspheres with combined magnetic resonance imaging (MRI) as well as controlled anti-cancer drug release functionality confined... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
AbstractThe complexity of cancer therapies has vastly expanded in the last decade, along with type and severity of cardiac toxicities associated with these treatments. Prevention of pre-clinical cardiotoxicity may improve cardiovascular outcomes and circumvent the decision to place life-sustaining chemotherapeutic agents on hold, making the early detection of cancer therapeutic related cardiac toxicity with non-invasive imaging essential to the care of these patients. There are several established methods of cardiac imaging in the areas of nuclear cardiology, echocardiography, computed tomography, and cardiac magnetic reso...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Stringent reaction condition of effective Fenton reaction (the pH range of 3-4) hinders its further application in cancer therapy. Therefore, how to improve the efficiency of Fenton reaction in tumor site has been the main obstacle of chemodynamic therapy (CDT). Herein, we report biocompatible one-dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)- and photothermal (PT)-enhanced Fenton properties and excellent photothermal conversion efficiency (56.6%) in the NIR II window, showing remarkably synergistic therapeutic properties. Additionally, FP NRs can be used as excellent photoacou...
Source: Angewandte Chemie - Category: Chemistry Authors: Tags: Angew Chem Int Ed Engl Source Type: research
Publication date: 10 February 2019Source: International Journal of Pharmaceutics, Volume 556Author(s): Mariano Licciardi, Cinzia Scialabba, Roberto Puleio, Giovanni Cassata, Luca Cicero, Gennara Cavallaro, Gaetano GiammonaAbstractHuman colon cancer is one of the higher aggressive solid tumors, whose high mortality, much like many other solid tumors, results from metastasis formation. To reduce this high mortality, more effective chemotherapy, allowing a specific tumor accumulation and an efficient early-stage medical imaging as well, are still needed. At this regard, stimuli-responsive nanocarriers for anticancer drug deli...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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