Wendy Atkin obituary

Epidemiologist whose research led to a breakthrough in bowel cancer screening programmes worldwide“Breakthrough” is an overused word when applied to medical advances. But in the case of the2010 trial of a new screening test for bowel cancer led by Wendy Atkin, professor of gastrointestinal epidemiology atImperial College London, who has died of acute myeloid leukaemia aged 71, it is fully deserved. Its impact will be felt by millions. The trial was the first in the world to show that bowel cancer – the second biggest cancer killer in the UK – could be prevented with a simple, five-minute test.The examination – where a sigmoidoscope (a camera mounted on a thin, flexible tube) is inserted into the rectum to detect polyps, which are then ablated (burnt) or snipped off – is now being offered to all 55- to 60-year-olds in England after a follow-up study showed it reduced deaths from bowel cancer by 43% f or as long as 17 years after screening, making it the most effective of all cancer screening tests. In the lower bowel, the test prevented half of potential cancers from developing in that area.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Cancer research Health Medical research Science Source Type: news

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Publication date: Available online 3 July 2020Source: European Journal of RadiologyAuthor(s): Dorothy Ibifuro Makanjuola, Abdulmohsen Alkushi, Khalid Al Anazi
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusions: We demonstrated a workflow for HIFU treatment of the porcine pancreas in-vivo under MRI-guidance. This development bears significance for the development of MR-guided HIFU interventions on the pancreas as the pig is the preferred animal model for the translation of pre-clinical research into clinical application. PMID: 32619373 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Authors: Li Y, Wang D, Li X Abstract Lung cancer has attracted a lot of attention because of its high morbidity and mortality. The emergence of RFA provides a new treatment for unresectable NSCLC patients. In addition to killing in situ lung tumors, RFA also provides new immuno-activated antigens, for the treatment of lung cancer. It changes the tumor microenvironment and activates the entire immune system of patients. The peripheral blood cell count is easy to achieve and the blood cells are important in tumor immunity, which changes after RFA. On the one hand, the changes in blood cells identify the immune change...
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Abstract Previous studies evaluating staging methods of lung cancer have focused on mediastinal disease. We explored the added value of endoscopic techniques after PET scan in the evaluation of N1 nodal stations in 276 patients with a radiologically normal mediastinum demonstrating a potential stage shift in 20% of patients. PMID: 32613092 [PubMed]
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Radiat Oncol Source Type: research
Conclusions: Adding SRT to RP does not seem to result in other than acceptable side-effects in the majority of men receiving SRT when taking a long follow-up time (median 10 years after surgery) into account. However, a subset of men develop severe side-effects where rectal bleeding dominates. PMID: 32619133 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Conclusion: The addition of k to established clinical variables significantly improves the possibility to predict treatment outcome after SRT and could be used to personalize future therapies. PMID: 32613088 [PubMed]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Radiat Oncol Source Type: research
CONCLUSION: The promising anticancer potential of helenalin in various preclinical studies may open new avenues for therapeutic interventions in different tumors. Thus clinical trials validating its tumor suppressing and chemopreventive activities particularly in conjunction with standard therapies, are immediately required. PMID: 32614752 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research
This study aimed to determine the immune profiles of advanced thyroid cancers using fluorescent multiplex immunohistochemistry (F-MIHC) and multispectral imaging (MSI). METHODS: Twenty-eight tissue samples were collected from 12 patients who had DTC with distant metastasis and from 16 with ATC. The samples were assessed using F-MIHC and MSI with antibodies against the cell surface molecules, cluster of differentiation (CD) 4, CD8, programmed cell death (PD-1), PD ligand 1 (PD-L1), forkhead box protein (Foxp)3, and cytokeratin (CK). The expression of PD-L1 was evaluated using tumor proportion score (TPS) and combined po...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Publication date: Available online 4 July 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Junjun Yang, Yang yang, Lu Wang, Qiuchen Jin, Minghui Pan
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 3 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J.-Y. Fu, L. Zhu, J. Li, P.-Q. Chen, C.-Y. Zhang, W.-T. Shi, S.-K. Shen, C.-P. Zhang, Z.-Y. Zhang
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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