Short-acting bronchodilators for the management of acute exacerbations of chronic obstructive pulmonary disease in the hospital setting: systematic review

AbstractBackgroundCurrently, there is a lack of guidelines for the use of short-acting bronchodilators (SABD) in people admitted to hospital for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), despite routine use in practice and risk of cardiac adverse events.AimTo review the evidence that underpins use and optimal dose, in terms of risk versus benefit, of SABD for inpatient management of AECOPD and collate the results for future guidelines.MethodsMedline, Embase, the Cochrane Central Register of Controlled Trials,clinicaltrials.gov and International Clinical Trials Registry Platform were searched (inception to November 2017) for published and ongoing studies. Included studies were randomised controlled trials or controlled clinical trials investigating the effect of SABD ( β2-agonist and/or ipratropium) on inpatients with a diagnosis of AECOPD. This review was undertaken in accordance with PRISMA guidelines and a pre-defined protocol. Due to heterogeneous methodologies, meta-analysis was not possible so the results were synthesised qualitatively.ResultsOf 1378 studies identified, 10 met inclusion criteria. Narrative synthesis of 10 studies revealed no significant differences in most outcomes of interest relative to dose, delivery via inhaler or nebuliser, and type of β2-agonist used. However, some evidence demonstrated significantly increased cardiac side effects with increased dosage of β2-agonist (45% versus 24%),P
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research

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Authors: Vandenbos F, Nicolaï C PMID: 31727553 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
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Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
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Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
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Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Researchers at Worcester Polytechnic Institute have developed a prototype wireless, flexible oxygen sensor the size of a band aid. The device can be stuck to the skin and can wirelessly monitor blood oxygen levels and transmit data through the intern...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Critical Care Emergency Medicine Materials Pediatrics Source Type: blogs
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Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
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Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
Highlights the work and story of Grace Anne Dorney Koppel, who was diagnosed with Chronic Obstructive Pulmonary Disease (COPD) in 2001. Since then, she has become a spokeswoman and advocate for patients with COPD, cofounding 12 pulmonary rehabilitation centers with her husband, and focusing on placing them in rural communities.
Source: News stories via the Rural Assistance Center - Category: Rural Health Source Type: news
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