UCLA research suggests widely used breast cancer therapy doesn ’t cause cognitive decline

UCLA researchers have found that commonly used hormone therapies for women diagnosed with breast cancer do not appear to cause significant cognitive dysfunction following the treatment.Endocrine therapy has become an essential part of treatment for the many women diagnosed with hormone-receptor positive breast cancer, in which hormones, such as estrogen, promote cancer growth. The endocrine treatment helps lower the recurrence and reduce the risk of death from breast cancer by interfering with how a woman ’s own hormones can continue to support the growth of dormant cancer cells. Yet, there has been limited evidence on whether this therapy has substantial negative effects on brain function.UCLAKathleen Van DykThe study, published today in the journal Cancer, is one of the largest and longest studies to address the question of whether endocrine therapy is associated with cognitive changes. The team followed breast cancer survivors for up to six years and found no cognitive differences over time between breast cancer survivors who received endocrine therapy and those who did not.“Women are often recommended to stay on this treatment for five to 10 years, so risk to cognitive health can be a big concern,” said lead author Kathleen Van Dyk, a neuropsychologist at the Semel Institute of Neuroscience and Human Behavior and the UCLA Jonsson Comprehensive Cancer Center. “Th is study provides some big-picture reassurance for the many women who are taking and wi...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Publication date: Available online 23 March 2019Source: Seminars in Cancer BiologyAuthor(s): Daniela Grimm, Johann Bauer, Petra Wise, Marcus Krüger, Ulf Simonsen, Markus Wehland, Manfred Infanger, Thomas J. CorydonAbstractCancer is a heavy burden for humans across the world with high morbidity and mortality. Transcription factors including sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) proteins are thought to be involved in the regulation of specific biological processes. The deregulation of gene expression programs can lead to cancer development. Here, we review the role of the SOX family ...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Contributors : Harihar Basnet ; Lin Tian ; Joan Massagu éSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMetastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq) for in situ analysis with unprecedented sensitivity. Flura-seq utilizes cytosine deaminase (CD) to convert fluorocytosine to fluorouracil, covalently labeling nascent RNA for purification and s...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
Artificial intelligence (AI) and radiomics can identify which non-small cell...Read more on AuntMinnie.comRelated Reading: AI may predict lymph node metastasis in gastric cancer AI singles out high-risk prostate cancer on mpMRI AI can predict breast cancer molecular subtypes on MRI AI can differentiate glioblastoma, brain metastasis AI uses features outside nodules to predict malignancy
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ConclusionOur findings suggest that patients with higher prechemotherapy DHEAS levels had a lower odds of developing self ‐perceived cognitive impairment. Future studies are required to further investigate the effect of DHEA(S) on specific cognitive domains and to validate our findings in independent cohorts.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research
I plead guilty to expounding on the biochemical vulnerabilities and abnormalities in neural wiring of depression to make the case that it is a legitimate illness alongside lupus, breast cancer, or psoriatic arthritis. I thought I was doing a good thing by quoting experts like Peter Kramer, M.D, who believes that because depression can be associated with the loss of volume in parts of the brain, it is the “most devastating disease known to mankind.” My intention, like so many other mental health advocates I know, was to use science as a tool to lessen stigma. But is that really effective? Proof of the Madness I ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Depression General Mental Health and Wellness Psychiatry Psychology Research Self-Help Treatment biogenetic theory Depressive Episode Mental Illness Mood Disorder Stereotypes Stigma Source Type: blogs
This study examined the acute effect of chemotherapy on hippocampal and subfield functional connectivity and neuropsychological status in breast cancer patients (BC). This IRB approved study included 29  BC and 25 age matched healthy controls (HCs) who underwent resting state functional magnetic resonance imaging (Rs-fMRI), neuropsychological tests and blood examinations at baseline and one week after completing chemotherapy or in the same time interval. Within-group comparisons and group-by-time interactions analysis of hippocampus- and subregion- based functional connectivity were performed between the two groups. F...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
We report a case of a patient with a history of stage IIA infiltrating lobular carcinoma of the right breast presenting with a metastatic lesion in the right adductor magnus. She was treated four years prior to the onset of the metastases with a modified radical mastectomy but refused postoperative chemotherapy or adjunctive radiation. PMID: 30856097 [PubMed - as supplied by publisher]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
A 79-year-old woman with a history of anxiety, depression, and chronic obstructive pulmonary disease, as well as a remote history of breast cancer treated with lumpectomy and radiation, presented to her primary care physician with new right upper  quadrant abdominal pain. Abdominal ultrasound identified 3 liver lesions, with MRI confirmation. Computed tomography–guided liver biopsy identified a diagnosis of small cell carcinoma, positive for synaptophysin and chromogranin. Positron emission tomography/computed tomography identified a 3.3- cm left hilar mass with mediastinal lymphadenopathy and concern for lympha...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
CONCLUSION: RCVS is difficult to diagnose given its wide array of symptoms and multifactorial etiology. In this case, RCVS plus SAH is associated with the use of anastrozole. So far there are no reported cases of aromatase inhibitors associated with this pathology and should be reported in the literature for pharmacovigilance. PMID: 30855709 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
avath P, Tung N, Pohlmann PR, Burns R, Rimawi MF, Krop IE, Wolff AC, Winer EP, Lin NU, Translational Breast Cancer Research Consortium Abstract PURPOSE: Evidence-based treatments for metastatic, human epidermal growth factor receptor 2 (HER2)-positive breast cancer to the CNS are limited. We previously reported modest activity of neratinib monotherapy for HER2-positive breast cancer brain metastases. Here we report the results from additional study cohorts. PATIENTS AND METHODS: Patients with measurable, progressive, HER2-positive brain metastases (92% after receiving CNS surgery and/or radiotherapy) received...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
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