Brain Atrophy in Natalizumab ‐treated Patients with Multiple Sclerosis: A 5‐year Retrospective Study

CONCLUSIONOur results contribute to the increasing knowledge of PBVCs in natalizumab ‐treated MS patients. Our data suggests that after a significant PBVC decrease in the first year, brain atrophy rates show a slowdown during long‐term follow‐up.
Source: Journal of Neuroimaging - Category: Radiology Authors: Tags: Short Communication Source Type: research

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CONCLUSIONS: BICAMS scores are associated with specific cortical areas, the cognitive domain matching the known functions of the cortical area. Specific cognitive impairments in MS may be associated with specific cortical regions, themselves influenced by white matter inflammatory lesions and demographical parameters (age, sex, education level).PMID:34657733 | DOI:10.1016/j.neurol.2021.06.014
Source: Revue Neurologique - Category: Neurology Authors: Source Type: research
There is growing interest in imaging multiple sclerosis (MS) through the ultra-high-field (UHF) lens, which currently means a static magnetic field strength of 7 T or higher. Because of higher signal-to-noise ratio and enhanced susceptibility effects, UHF magnetic resonance imaging improves conspicuity of MS pathological hallmarks, among them cortical demyelination and the central vein sign. This could, in turn, improve confidence in MS diagnosis and might also facilitate therapeutic monitoring of MS patients. Furthermore, UHF imaging offers unique insight into iron-related pathology, leptomeningeal inflammation, and spina...
Source: Investigative Radiology - Category: Radiology Tags: Specialty Topic Review Articles Source Type: research
ConclusionThe performance of the CNN improved significantly for infratentorial lesions when specifically trained on infratentorial lesions using a T1 image as an additional input and matches the detection performance of experienced raters. Furthermore, for infratentorial lesions the CNN was more robust against repeated scans than experienced raters.Key Points•A 3D convolutional neural network was trained on MRI data from 1809 patients (156 different scanners) for the quantification of supratentorial and infratentorial multiple sclerosis lesions.•Inter-rater variability was higher for infratentorial lesions than f...
Source: European Radiology - Category: Radiology Source Type: research
Conclusions3D-FLAIR2 is an easily applicable time-sparing MR post-processing method to improve cortical lesion detection. Larger sampled studies are warranted to validate the sensitivity and specificity of 3D-FLAIR2.
Source: Journal of Neurology - Category: Neurology Source Type: research
DISCUSSION: The correlation between T1 hypointense lesions' mean volume and EDSS was interpreted as low to slightly moderate. The certainty of the evidence was judged to be high.PMID:34605190 | DOI:10.1111/cns.13734
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
In conclusion, blink reflex was found to be a very sensitive and useful diagnostic tool in the assessment of brainstem structures, especially because abnormalities are seen not only in CDMS but also in CIS. Slowing of the late component as a sign of dysfunction in the efferent part of the reflex arc is not very specific but is a highly sensitive finding.PMID:34588716 | PMC:PMC8305361 | DOI:10.20471/acc.2021.60.01.02
Source: Acta Clinica Croatica - Category: General Medicine Authors: Source Type: research
In conclusion, blink reflex was found to be a very sensitive and useful diagnostic tool in the assessment of brainstem structures, especially because abnormalities are seen not only in CDMS but also in CIS. Slowing of the late component as a sign of dysfunction in the efferent part of the reflex arc is not very specific but is a highly sensitive finding.PMID:34588716 | PMC:PMC8305361 | DOI:10.20471/acc.2021.60.01.02
Source: Acta Clinica Croatica - Category: General Medicine Authors: Source Type: research
In conclusion, blink reflex was found to be a very sensitive and useful diagnostic tool in the assessment of brainstem structures, especially because abnormalities are seen not only in CDMS but also in CIS. Slowing of the late component as a sign of dysfunction in the efferent part of the reflex arc is not very specific but is a highly sensitive finding.PMID:34588716 | PMC:PMC8305361 | DOI:10.20471/acc.2021.60.01.02
Source: Acta Clinica Croatica - Category: General Medicine Authors: Source Type: research
In conclusion, blink reflex was found to be a very sensitive and useful diagnostic tool in the assessment of brainstem structures, especially because abnormalities are seen not only in CDMS but also in CIS. Slowing of the late component as a sign of dysfunction in the efferent part of the reflex arc is not very specific but is a highly sensitive finding.PMID:34588716 | PMC:PMC8305361 | DOI:10.20471/acc.2021.60.01.02
Source: Acta Clinica Croatica - Category: General Medicine Authors: Source Type: research
In conclusion, blink reflex was found to be a very sensitive and useful diagnostic tool in the assessment of brainstem structures, especially because abnormalities are seen not only in CDMS but also in CIS. Slowing of the late component as a sign of dysfunction in the efferent part of the reflex arc is not very specific but is a highly sensitive finding.PMID:34588716 | PMC:PMC8305361 | DOI:10.20471/acc.2021.60.01.02
Source: Acta Clinica Croatica - Category: General Medicine Authors: Source Type: research
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