Post-Translational Modification, Phase Separation, and Robust Gene Transcription.

Post-Translational Modification, Phase Separation, and Robust Gene Transcription.
Trends Genet. 2018 Nov 23;:
Authors: Singh HR, Ostwal YB
Abstract
A few recent reports reveal fundamental new insights into the intricate regulatory mechanisms that govern RNA polymerase II (Pol II)-mediated gene transcription. Whereas a histidine-rich domain (HRD) triggers phase separation, promoting transcription elongation, a phosphatase switch promotes transcription termination. A paradigm that might govern the underlying mechanisms leading to robust gene transcription is now starting to emerge.
PMID: 30477958 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - November 23, 2018 Category: Genetics & Stem Cells Authors: Singh HR, Ostwal YB Tags: Trends Genet Source Type: research