Protecting the gains: What changes are needed to prevent a reversal of the downward cardiovascular disease mortality trend?

ConclusionsGiven demographic and risk prevalence changes, increasing access and adherence to current preventative therapeutics could slow the expected mortality increase, but new therapies may be needed to maintain the downward trend in CVD deaths.
Source: Clinical Cardiology - Category: Cardiology Authors: Tags: CLINICAL INVESTIGATIONS Source Type: research

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In this study, we reviewed in-vitro and in-vivo studies, as well as clinical reports pertaining to the antifungal efficacy of statins. In addition, we have addressed various modulators of statin anti-fungal activity and the potential mechanisms responsible for their anti-fungal effects. In general, statins do possess anti-fungal activity, targeting a broad spectrum of fungal organisms including human opportunistic pathogens such as Candida spp. and Zygomycetes, Dermatophytes, alimentary toxigenic species such as Aspergillus spp., and fungi found in device implants such as Saccharomyces cerevisiae. Statins have been shown t...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Telephone intervention linked to rise in men ’s vegetable consumption but not to drop in risk of progression Related items fromOnMedica Less regular PSA screening puts men at risk NICE guidance delays hinder good diabetes care Population weight control best for cutting diabetes prevalence Starting statins not beneficial in many older adults NHS must hold CCGs accountable for poor diabetes care
Source: OnMedica Latest News - Category: UK Health Source Type: news
In this study, we developed a high-throughput small molecule screen for YAP inhibitors in primary human lung fibroblasts (HLF). Multiple hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) were found to inhibit YAP nuclear localization via induction of YAP phosphorylation, cytoplasmic retention and degradation. We further show that the mevalonate pathway regulates YAP activation, and that simvastatin treatment reduces fibrosis markers in activated HLF and in the bleomycin mouse model of pulmonary fibrosis. Finally, we show simvastatin modulates YAP in vivo in mouse lung fibroblasts. Our results hi...
Source: American Journal of Respiratory Cell and Molecular Biology - Category: Molecular Biology Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
Whether you have a stomachache, a wrist sprain or a chronic disease, one of the first things doctors and nurses will do at an appointment is take your temperature. A normal temperature means your body is humming along the way it should. A higher temperature means you have a fever, and shows your body could be fighting an infection. And since 1871, “normal” has meant 98.6°F (37°C). That number was determined by a German physician, based on millions of readings from 25,000 German patients, taken by sticking thermometers under their arms. When doctors in the U.S. and Europe repeated the experiment in local...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fever health inflammation Research Source Type: news
A new drug used as a twice a year injection is being tried out in UK by the NHS as an alternative to statins.  Initial reports suggest reduction of bad cholesterol by more than 50 % within weeks of the injection.
Source: cochinblogs - Category: Radiology Source Type: blogs
CONCLUSION: This review highlights some alternatives to address patients' intolerance to statins; however, these are mostly based on recommendations with low to moderate evidence. Therefore, further research with randomized studies involving greater number of patients is required, in order to obtain a more robust recommendation. PMID: 31928603 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Valentina et  al. [1] observed that treatment of patients with atorvastatin significantly improved inflammatory profile in epicardial adipose tissue. This finding may reveal an unexpected role of statin in adipose inflammation, whereas the underlying mechanisms remain unknown.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Conclusion Nonagenarians and centenarians in the Cilento region had a healthy metabolic profile and a low prevalence of clinical cardiovascular disease. Even among nonagenarians and centenarians with structural heart abnormalities, report of symptoms is low. Larger studies in the Cilento population may help elucidate the mechanisms underlying cardiovascular health in the oldest old.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Epidemiology Source Type: research
There are inconsistent results on the association between statin use and the risk of dementia. Power et al. conducted a systematic review and concluded that randomized controlled trials (RCTs) and well-conducted observational studies did not support a ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
A Mayo Clinic specialist discusses the use of coenzyme Q10 to prevent statin side effects.
Source: - Ask a Specialist - Category: Consumer Health News Source Type: news
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