The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single ‐nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta‐analysis

HOX transcript antisense intergenic RNA (HOTAIR) rs4759314 increased susceptibility to breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC) in some patients, and rs029778 and rs1899663 also increased susceptibility to some extent. Three functional polymorphisms, rs12826786, rs7958904, and rs874945, were not correlated with an effect on patient susceptibility to BC, CC, and OC. AbstractRecent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women ’s health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence of it is increasing. We performed a meta‐analysis to clarify the relationship between lncRNA HOTAIR expression and BC, CC, and OC susceptibility. We thoroughly searched P ubMed, Embase, and the Cochrane Library to obtain the relevant literature. We extracted data from case groups and control groups for each single‐nucleotide polymorphism (SNP) (rs4759314, rs920778, rs189663, rs12826786, rs7958904, and rs874945) and compared the relationship between alleles, codomin ance models, dominant and invisible models and BC, CC, and OC susceptibility. Our study included 11 studies with a total of 5322 patients. There was a significant association between the rs4759314 polymorphism of HOTAIR and susceptibility to BC, CC, and OC (codominant model: AG/AA odds ratio [OR]  =...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research