LncRNA MALAT1 promotes oxidized low ‐density lipoprotein‐induced autophagy in HUVECs by inhibiting the PI3K/AKT pathway

In this study, we observed that autophagy was upregulated and MALAT1 expression was markedly increased in HUVECs treated with ox‐LDL. The ox‐LDL‐induced autophagy of HUVECs is significantly associated with the PI3K/AKT pathway. Fur thermore, we found that MALAT1 overexpression inhibited PI3K, Akt and p70S6K phosphorylation and downregulated RHEB expression, simultaneously increasing ox‐LDL‐induced autophagy. MALAT1 silencing caused higher phosphorylated PI3K, Akt and p70S6K levels, upregulated RHEB expression and markedly suppressed autophagy. These results indicated that lncRNA MALAT1 promotes ox‐LDL‐induced autophagy in HUVECs partly through the PI3K/AKT signaling pathway.
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research