Life span pigmentation changes of the substantia nigra detected by neuromelanin ‐sensitive MRI

Conclusions: Using optimized neuromelanin MRI in a life span sample, we demonstrate a strong age effect with inverted U ‐shaped SNpc pigmentation‐related contrast from childhood to old age. This age trajectory of physiological SNpc pigmentation needs to be taken into account for diagnostic applications of depigmentation. The study also paves the way for systematic investigations of the mechanisms of neuromelanin in healthy and pathological brain development and aging. © 2018 International Parkinson and Movement Disorder Society

https://onlinelibrary.wiley.com:443/doi/abs/10.1002/mds.27502?af=R

Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Yue Xing, Abdul Sapuan, Rob A. Dineen, Dorothee P. Auer Tags: Research Article Source Type: research