Progressively Disrupted Somatodendritic Morphology in Dopamine Neurons in a Mouse Parkinson's Model

Conclusions: A progressive and severe decline in somatodendritic morphology occurs prior to cell death, but is not responsible for the subtle decrements observable in the earliest stages of neurodegeneration. This work could help identify the ideal time window for specific treatments to halt disease progression and avert debilitating motor deficits in Parkinson's patients. © 2018 International Parkinson and Movement Disorder Society

Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: William B. Lynch, Christopher W. Tschumi, Amanda L. Sharpe, Sarah Y. Branch, Cang Chen, Guo Ge, Senlin Li, Michael J. Beckstead Tags: Research Article Source Type: research