Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

Conclusions: Anle138b reduces α‐synuclein accumulation in PLP‐hαSyn mice, leading to neuroprotection, reduction of microglial activation, and preservation of motor function supporting the use of anle138b in a future clinical trial for MSA. © 2018 The Authors.Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Antonio Heras ‐Garvin, Daniel Weckbecker, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Armin Giese, Gregor K. Wenning, Nadia Stefanova Tags: Research Article Source Type: research