GSTP1 gene methylation and AHR rs2066853 variant predict resistance to first generation somatostatin analogs in patients with acromegaly

ConclusionsIn acromegaly,GSTP1 gene methylation associates with resistance to SSA treatment, especially in patients carrying also theAHR rs2066853 variant, and with increased prevalence of colonic polyps and diabetes mellitus.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research