c ‐Met inhibition is required for the celecoxib‐attenuated stemness property of human colorectal cancer cells

In this study, we found that among these NSAIDs, celecoxib has t he most potency for CSC inhibition of CRC cells, largely correlating to inhibition of c‐Met, not COX‐2. Further analysis reveals that c‐Met activity was required for basal CSC property. Silence of c‐Met blocked whereas overexpression of c‐Met enhanced the celecoxib‐inhibited CSC propert y. Collectively, these results not only first elucidate the mechanism underlying celecoxib‐inhibited CSC but also indicate c‐Met as a critical factor for the CSC property of CRC cells.

Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yueh ‐Ming Lin, Chien‐Chang Lu, Yi‐Ping Hsiang, Shu‐Chuan Pi, Chih‐I Chen, Kung‐Chuan Cheng, Hsiao‐Lin Pan, Pei‐Hsuan Chien, Yun‐Ju Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research