Arterial Identity Of Hemogenic Endothelium: A Key To Unlock Definitive Hematopoietic Commitment In hPSC Cultures

Derivation of human embryonic stem cells (hESCs) 20 years ago [1] followed by advances in cellular reprogramming to generate human induced pluripotent stem cells (hiPSCs) [2-5] have created alternative platforms for producing blood cells for transfusion, immunotherapies and transplantation. Although the feasibility of generating myeloid, T lymphoid, and engraftable blood cells from human pluripotent stem cells (hPSCs) has been demonstrated [6-14], scalable production of definitive hematopoietic cells, including adult-type red blood cells, megakaryocytes, T cells, and hematopoietic stem cells (HSCs) with robust multilineage engraftment potential remains a significant challenge.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research