Thinking through acidic Ca2+ stores

Glutamate signaling regulates neuronal activity and synaptic plasticity, which underlies learning and memory. In this issue of Science Signaling, Foster et al. found that metabotropic glutamate receptors mediate long-term potentiation in hippocampal neurons by mobilizing acidic endolysosomal Ca2+ stores through the intracellular messenger NAADP.

http://stke.sciencemag.org/cgi/content/short/11/558/eaau3342?rss=1

Source: Signal Transduction Knowledge Environment - November 27, 2018 Category: Science Authors: Patel, S., Brailoiu, E. Tags: STKE Focus Source Type: news