The effect of lipotropic agents on the nutritional induction of fatty liver syndrome in broilers

This study hypothesized that the application of lipotropic agents may help broiler chicks to efficiently utilize the high-energy diets. A total of 100-day-old broiler chicks were randomly divided into five equal groups; negative control, positive control (fed on high-energy diet), and three groups fed on high-energy diet with supplemental lipotropic agents (100  mg/kg b.wt. carnitine asl-carnitine or 1000  mg/kg b.wt. choline as choline chloride or combination of both). Average body weight (BW) and daily weight gain (BWG) were recorded during the 42-day experimental period. Alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activity, beside the serum level of total protein, albumin, globu lin and A/G ratio, lipogram, and histopathological examination were carried out. The BW and BWG were decreased with an increase in ALT and ALP activity in the positive control group. Proteinogram was not affected; meanwhile, a significant increase in triglyceride (TG) was observed. Dietary supplemen tation of these lipotropic agents (carnitine and choline) improved all these parameters. Choline and carnitine co-treatment showed better effect than each one individually. Our histopathological examination confirms the results. Interestingly, the modulation of lipotropic agents for co-administratio n considers a new mechanism with a pathway key to overcome on hepatic fat accumulation.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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ConclusionThe ruthenium(II) complex showed beneficial effects as it ameliorated and prevented the progression of diabetes-related liver derangements while eliminating the hepatotoxicity associated with the use of metal compounds. However, further studies are still required to further determine the physiological mechanisms behind this effect.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
Authors: Damaskos C, Garmpis N, Kollia P, Mitsiopoulos G, Barlampa D, Drosos A, Patsouras A, Gravvanis N, Antoniou V, Litos A, Diamantis E Abstract The globalization of the Western lifestyle has resulted in a dramatic increase of diabetes mellitus, a complex, multifactorial disease. Diabetes mellitus is a condition often associated with disorders of the cardiovascular system. It is well established that three quarters of diabetics, aged over 40, will die from cardiovascular disease and are more likely than non-diabetics to die from their first cardiovascular event. Therefore, risk stratification is necessary to ind...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Authors: Sun L, Yin H, Liu M, Xu G, Zhou X, Ge P, Yang H, Mao Y Abstract Albumin is the most abundant plasma protein and albumin infusion is commonly used. Conventionally, the biologic and therapeutic effects of albumin have been thought to be due to its oncotic properties. However, albumin has a variety of biologic functions, including molecular transport, anti-oxidation, anti-inflammation, endothelial stabilization, anti-thrombotic effects, and the adjustment of capillary permeability. Despite this, the functions of albumin have not been thoroughly investigated. Recent studies have shown non-alcoholic fatty liver...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Authors: Fukaishi T, Minami I, Masuda S, Miyachi Y, Tsujimoto K, Izumiyama H, Hashimoto K, Yoshida M, Takahashi S, Kashimada K, Morio T, Kosaki K, Maezawa Y, Yokote K, Yoshimoto T, Yamada T Abstract We herein report a case of a 28-year-old man with generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement. He showed symptoms of generalized lipodystrophy around onset of puberty. His body mass index was 11.9 kg/m2, and he had a short stature, birdlike facies, dental crowding due to micrognathia, partial graying and loss of hair, and a high-pitched voice, all of which are typical features o...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Condition:   Fatty Liver Interventions:   Procedure: focused ultrasound, diet and exercise;   Procedure: diet and exercise Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Fatty Liver Intervention:   Other: No Intervention Sponsor:   ProgenaBiome Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Fatty Liver Interventions:   Procedure: focused ultrasound, diet and exercise;   Procedure: diet and exercise Sponsor:   Cairo University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Look at Pamela’s spectacular progress that began with the Wheat Belly 10-Day Grain Detox and posted on the Detox Facebook page, showing her standing in ONE LEG of her old pants! Her experience illustrates just how awful health, weight, and life can get on the wrong way of eating, but also just how dramatic the changes can be when you finally get it right. “It’s a long one, but hang with me! “I’ve been debating whether to share this picture or not… I found my ‘before’ pants and decided to see what would happen… I thought I’d take another picture after I put on so...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune Detox Inflammation joint pain Weight Loss wheat belly Source Type: blogs
Conclusions: Key HIV-related parameters reflective of nonacute infection (increased duration of HIV and duration of antiretroviral therapy use) or relatively reduced immunologic function (lower CD4 count) were linked to reduced expression of brown and beige fat gene in the abdominal subcutaneous adipose depot. Clinical Trial Registration: NCT01098045.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Translational Research Source Type: research
ConclusionsLiver stiffness and age were strongly predictive of subclinical atherosclerosis in all NAFLD, while LFC was an additional predictor in obese NAFLD patients. Our findings highlight that early CVD screening strategy should be established for NAFLD patients according to different BMIs.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
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