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We thank Dr Freeman for his interest in our systematic review and meta-analysis.1 In his letter, he refers to the study from Vancouver in which 9665 adults underwent endoscopy over 30 years and 234 (2.4%) of them showed mucosal changes compatible with celiac disease.1,2 As the author points out, those with known positive celiac serologic testing, an established diagnosis of celiac disease, and a family history of celiac disease were excluded.1,2 However, these patients were referred for upper endoscopy for evaluation of 1 or more of the following symptoms: diarrhea, abdominal pain, weight loss, dyspepsia, and so forth.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research