Optimization of a table-top x-ray fluorescence computed tomography (XFCT) system.

Optimization of a table-top x-ray fluorescence computed tomography (XFCT) system. Phys Med Biol. 2018 Nov 26;63(23):235013 Authors: Dunning CAS, Bazalova-Carter M Abstract Pencil beam x-ray fluorescence computed tomography (XFCT) has typically used a single spectrometer and prohibitively long scan times. However, detecting backscattered fluorescent x-rays from gold nanoparticles (AuNPs) using multiple spectrometers greatly reduces image noise and scan time. The arrangement of eight spectrometers for combined K-shell and L-shell XFCT was investigated along with a variety of conditions. A 2.5 cm-diameter cylindrical water phantom containing 4 mm-diameter vials with 0.1%-2% AuNP concentrations by weight was modeled by TOPAS, a GEANT4-based Monte Carlo software. The phantom was irradiated to 30 mGy by a 0.5 mm Pb-filtered 120 kVp and 1 mm Al-filtered 30 kVp 1 mm2 x-ray pencil beam to yield respective Au K-shell and L-shell fluorescent x-rays, with 50 0.5 mm translation and 2-degree rotation steps. Eight CdTe and silicon drift detector (SDD) spectrometers were placed 2.25 cm away from the isocentre. The respective energy resolution was applied to the detected energy spectra and the spectra were corrected for detector response before extracting the fluorescence signal. Three CdTe and SDD spectrometer configurations (isotropic/backscattered grid/backscattered row arrangements), two CdTe crystal sizes (9 mm2/25 mm2), two scanni...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research