Advances and challenges in drug design against tuberculosis: application of in silico approaches

Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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CONCLUSIONS: There is a need to improve respiratory infectious disease procedures in our study hospitals, especially in outpatient and emergency departments. PMID: 32459978 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
CONCLUSIONS: Body mass index and population density were inversely associated with pulmonary tuberculosis relapses in Cali. On the contrary, alcohol consumption increased the likelihood of tuberculosis relapses. PMID: 32463612 [PubMed - as supplied by publisher]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Authors: Román-González A, Toro JP, Arias LF Abstract La insuficiencia suprarrenal primaria es un defecto en la producción de glucocorticoides, mineralocorticoides y andrógenos sexuales. Los pacientes afectados por esta condición se caracterizan por concentraciones bajas de cortisol y deficiencia de aldosterona con hiponatremia e hiperpotasemia concomitantes. La etiología más común es el desarrollo de anticuerpos contra la enzima 21 hidroxilasa. Otra causa importante de la insuficiencia suprarrenal primaria son las enfermedades infecciosas, en especial en los ...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
This study sought to investigate the expression and diagnostic value of serum miR-145 in TB patients and explore the biological function of miR-145 using macrophages. Serum expression levels of miR-145 were estimated by quantitative real-time PCR. A receiver operating characteristic curve was plotted to evaluate the diagnostic accuracy of miR-145. This study further focused on the effects of miR-145 on cell viability and inflammation in macrophages upon Mtb infection, and explored the potential target gene of miR-145. Serum expression levels of miR-145 were decreased in TB patients, and the upregulated inflammatory cytokin...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Conditions:   Volatile Organic Compounds;   Radiography Interventions:   Device: electronic nose device;   Device: dig chest Xray with automated readings Sponsors:   Radboud University;   European Union;   ISPUP;   VHIR;   University Medical Center Groningen;   Laboratorio central de salud publica, Paraguay;   Instituto Nacional de Enfermedades Respiratorias y del Ambiente Juan Max Boetner;   National TB program Paraguay;   IICS Paragua...
Source: - Category: Research Source Type: clinical trials
Conclusion: OCTA may be superior to ICGA in the detection of CNV secondary to inflammatory situations. PMID: 32459550 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Publication date: Available online 28 May 2020Source: Neurología (English Edition)Author(s): J. Romero-Imbroda, T. Sagrario-Fustero, C. Del Canto-Pérez, M. Requena-Pou
Source: Neurologia - Category: Neurology Source Type: research
Traveling man: the Goodwill Ambassador shares a joke with two residents of a leprosarium in Krantau, Uzbekistan during a visit in 2013.By External SourceMay 29 2020 (IPS-Partners)   Warm greetings from Sasakawa Health Foundation in Tokyo. The 100th Issue of the WHO Goodwill Ambassador’s Newsletter has been published. Read special interviews with the Goodwill Ambassador and the UN Special Rapporteur on leprosy, and check out the Timeline of all that has happened since the first issue. My Journey Continues I started this newsletter in April 2003 to share information about the fight against leprosy. This marks th...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Health Source Type: news
[The Herald] Zimbabwe has appointed TB Champions as it steps up the fight against tuberculosis (TB), which remains one of the major causes of death.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Abstract Tuberculosis (TB) in pregnancy poses a substantial risk of morbidity to both the pregnant woman and the fetus if not diagnosed and treated in a timely manner. Assessing the risk of having Mycobacterium tuberculosis infection is essential to determining when further evaluation should occur. Obstetrician-gynecologists are in a unique position to identify individuals with infection and facilitate further evaluation and follow up as needed. A TB evaluation consists of a TB risk assessment, medical history, physical examination, and a symptom screen; a TB test should be performed if indicated by the TB evaluat...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
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