Association of galectin ‐3 with markers of myocardial function, atherosclerosis, and vascular fibrosis in patients with rheumatoid arthritis

ConclusionsIn a relatively well ‐controlled cohort of RA patients with low‐grade systemic inflammation and long‐standing disease, serum galectin‐3 might be useful as a marker of cardiac function and cardiovascular fibrosis.
Source: Clinical Cardiology - Category: Cardiology Authors: Tags: CLINICAL INVESTIGATIONS Source Type: research

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Publication date: Available online 15 January 2020Source: Canadian Journal of CardiologyAuthor(s): Ming-Jer Hsieh, Cheng-Hung Lee, Ming-Lung Tsai, Chang-Fu Kao, Wen-Ching Lan, Yu-Tung Huang, Wen-Yi Tseng, Ming-Shien Wen, Shang-Hung ChangAbstractBackgroundTumor necrosis factor inhibitors (TNFi) improve joints outcomes and reduce cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). However, 20-45% of RA patients are TNFi poor responders and have a significantly higher risk of CV events. In these TNFi non-responders, the use of second-line biological agents to improve synovial outcomes is supported by clinical...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionCHA2DS2‐VASc‐score accurately identifies in the mid‐term patients in sinus rhythm with RA/AS/PsA at different risks for CV and non‐CV mortality and hospitalization.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, the enhanced mice live somewhat longer than their unmodified peers, though not as much longer as is the case for the application of telomerase gene therapy. The mice do also exhibit reduced cancer risk, however. The scientists here class telomere shortening as a cause of aging, which is not a point universally agreed upon. Reductions in average telomere length in tissues looks much more like a downstream consequence of reduced stem cell activity than an independent mechanism. Researchers obtain the first mice born with hyper-long telomeres and show that it is possible to extend life without any geneti...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: A variety of chronic diseases may increase the risk of cellulitis after acupuncture. Physicians asked about past medical history before acupuncture might help to reduce cellulitis.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
If you’re like most people, you’ve seen a ton of direct-to-consumer (DTC) drug ads in recent years. They’re all over television, in magazines, online, on billboards, and slapped on the sides of buses, promoting treatments for arthritis, cancer, heartburn, psoriasis, flagging memory — and more. The deluge of drug ads can be overwhelming. Worse, the information is often incomplete, biased, or confusing. That’s why we’re launching the Harvard Health Ad Watch series to highlight some benefits and problems with health product advertisements. We’ll focus on the evidence behind the ads an...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Drugs and Supplements Men's Health Women's Health Source Type: blogs
CONCLUSION: The CHMs use was associated with lower risk of stroke for RA patients, suggesting that it could be integrated into conventional therapy to prevent subsequent stroke incident. PMID: 31331548 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
Editor's Summary by Howard Bauchner, MD, Editor in Chief of JAMA, the Journal of the American Medical Association, for the July 23, 2019 issue
Source: JAMA: This Week's Audio Commentary - Category: General Medicine Authors: Source Type: podcasts
ObjectiveRheumatoid arthritis (RA) is associated with increased cardiovascular event (CVE) risk. The impact of statins in RA is not established. We assessed whether atorvastatin is superior to placebo for the primary prevention of CVEs in RA patients.MethodsA randomized, double ‐blind, placebo‐controlled trial was designed to detect a 32% CVE risk reduction based on an estimated 1.6% per annum event rate with 80% power atP50 years or with a disease duration of>10 years who did not have clinical atherosclerosis, diabetes, or myopathy received atorvastatin 40 mg daily or matching placebo. The primary end point was a c...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
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