Significantly lower serum and hair magnesium levels in children with attention deficit hyperactivity disorder than controls: A systematic review and meta-analysis

Publication date: Available online 26 November 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Yu-Hui Huang, Bing-Yan Zeng, Dian-Jeng Li, Yu-Shian Cheng, Tien-Yu Chen, Hsin-Yi Liang, Wei-Chieh Yang, Pao-Yen Lin, Yen-Wen Chen, Ping-Tao Tseng, Ching-Hua LinAbstractThe pathophysiology of attention deficient hyperactivity disorder (ADHD) is still obscure. Some studies have discussed that magnesium levels are lower in the serum and erythrocytes of children with ADHD. However, these findings are controversial. The aim of our study is to identify whether magnesium levels are in fact lower in children with ADHD. We conducted a thorough search of the literature and examined the connection between magnesium insufficiency and ADHD. A total of twelve studies were included into the current meta-analysis. The results of our meta-analysis found that peripheral blood magnesium levels, either in plasma, serum, or whole blood, of children diagnosed with ADHD were significantly lower than those in controls (k = 8, Hedges' g = −0.547, 95% CI = −0.818 to −0.276, p < .001). The subgroup meta-analysis with serum sample sources also suggested that peripheral serum magnesium levels of children diagnosed with ADHD were significantly lower than those in controls (k = 6, Hedges' g = −0.733, 95% CI = −0.911 to −0.555, p < .001). The subgroup meta-analysis focusing on subjects with ADHD diagnosed by definite diagnosti...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research