MRI-based Evaluation of Structural Degeneration in the Ageing Brain: Pathophysiology and Assessment.

MRI-based Evaluation of Structural Degeneration in the Ageing Brain: Pathophysiology and Assessment. Ageing Res Rev. 2018 Nov 22;: Authors: Grajauskas LA, Siu W, Medvedev G, Guo H, D'Arcy RC, Song X Abstract Advances in MRI technology have significantly contributed to our ability to understand the process of brain ageing, allowing us to track and assess changes that occur during normal ageing and neurological conditions. This paper focuses on reviewing structural changes of the ageing brain that are commonly seen using MRI, summarizing the pathophysiology, prevalence, and neuroanatomical distribution of changes including atrophy, lacunes, white matter lesions, and dilated perivascular spaces. We also review the clinically accessible methodology for assessing these MRI-based changes, covering visual rating scales, as well computer-aided and fully automated methods. Subsequently, we consider novel assessment methods designed to evaluate changes across the whole brain, and finally discuss new directions in this field of research. PMID: 30472216 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research