Baby who giggled for 17 hours a day actually had a rare brain tumour that caused him to laugh

Gemma and Ed Young, of Somerset, thought their baby, Jack, was really joyful. But two years later, doctors found a small brain tumour, called  hypothalamic hamartoma.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In conclusion, CD133 promoted the upregulation of CSC/TSC-related genes in glioma cells, while enhancing the neurosphere-forming ability and in-vivo oncogenicity. PMID: 30891998 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
The abnormal growth of cells in the brain is known as brain tumor. A brain tumor is a kind of disease that can hit children, adults, and older adults. In this work, a proposed method for brain tumor detection and classification using MATLAB and based on magnetic resonance imaging plays an essential role in the brain-tumor disease diagnostic application that is based on manual and automatic detection. Moreover, various kinds of tumors exist so it is complicated to detect, and thus it is hard to make decisions. Correct segmentation and image enhancement give an accurate classification of brain tumor types. A probabilistic ne...
Source: Journal of Clinical Engineering - Category: Medical Devices Tags: FEATURE ARTICLES Source Type: research
This article summarizes recent developments and clinical applications of the most widely used amino acid radiotracers. While none of these agents are FDA approved in the United States, they are considered standard of care in Europe and other parts of the world with  >  10,000 studies being performed in some centers (Langen et al. in J Neurooncol 120(3):665–666, 2014).
Source: Current Radiology Reports - Category: Radiology Source Type: research
Abstract Recent clinical studies document the power of immunotherapy in treating subsets of patients with advanced cancers. In this context and with multiple cancer immunotherapeutics already evaluated in the clinic and a large number in various stages of clinical trials, it is imperative to comprehensively examine genomics data to better comprehend the role of immunity in different cancers in predicting response to therapy and in directing appropriate therapies. The approach we chose is to scrutinize the pathways and epigenetic factors predicted to drive immune infiltration in different cancer types using publicl...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
Publication date: 19 March 2019Source: Cell Reports, Volume 26, Issue 12Author(s): Amanda Linkous, Demosthenes Balamatsias, Matija Snuderl, Lincoln Edwards, Ken Miyaguchi, Teresa Milner, Batsheva Reich, Leona Cohen-Gould, Andrew Storaska, Yasumi Nakayama, Emily Schenkein, Richa Singhania, Stefano Cirigliano, Tarig Magdeldin, Ying Lin, Gouri Nanjangud, Kalyani Chadalavada, David Pisapia, Conor Liston, Howard A. FineSummaryThe prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a “normal” hu...
Source: Cell Reports - Category: Cytology Source Type: research
Recent studies have proposed several gene signatures as biomarkers for different grades of gliomas from various perspectives. However, most of these genes can only be used appropriately for patients with speci...
Source: BMC Medical Genomics - Category: Genetics & Stem Cells Authors: Tags: Research Source Type: research
Conclusion This minimally invasive approach can be used to achieve extensive resection with minimal morbidity for arguably the highest risk metastatic brain tumors. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
. Eisenmann High-grade glioma (HGG, WHO Grade III–IV) accounts for the majority of adult primary malignant brain tumors. Failure of current therapies to target invasive glioma cells partly explains the minimal survival advantages: invasive tumors lack easily-defined surgical margins, and are inherently more chemo- and radioresistant. Much work centers upon Rho GTPase-mediated glioma invasion, yet downstream Rho effector roles are poorly understood and represent potential therapeutic targets. The roles for the mammalian Diaphanous (mDia)-related formin family of Rho effectors have emerged in invasive/metastati...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsStereotactic frameless biopsy is a safe, feasible, and fast procedure to obtain a histological and molecular diagnosis.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
ConclusionA solitary cerebellum metastasis from primary gastric adenocarcinoma is a very rare presentation. Early detection of metastatic lesion and successful treatment is challenging.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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