Purinergic signaling in Alzheimer's disease.

Purinergic signaling in Alzheimer's disease.
Brain Res Bull. 2018 Nov 22;:
Authors: Erb L, Woods LT, Khalafalla MG, Weisman GA
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by three major histopathological markers: amyloid-β (Aβ) plaques, neurofibrillary tangles and gliosis in the central nervous system (CNS). It is now accepted that neuroinflammatory events in the CNS play a crucial role in the development of AD. This review focuses on neuroinflammatory signaling mediated by purinergic receptors (P1 adenosine receptors, P2X ATP-gated ion channels and G protein-coupled P2Y nucleotide receptors) and how therapeutic modulation of purinergic signaling influences disease progression in AD patients and animal models of AD.
PMID: 30472151 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - November 22, 2018 Category: Neurology Authors: Erb L, Woods LT, Khalafalla MG, Weisman GA Tags: Brain Res Bull Source Type: research