DNA Vaccine Reduces Tau and Beta-Amyloid in Alzheimer's Mice

This study is the culmination of a decade of research that has repeatedly demonstrated that this vaccine can effectively and safely target in animal models what we think may cause Alzheimer’s disease. I believe we’re getting close to testing this therapy in people.” ~ said Dr. Roger Rosenbe rg, founding Director of the Alzheimer’s Disease Center at UT Southwestern.What is the Difference Between Alzheimer ’s and DementiaThe study was conducted by the UT Southwestern ’s Peter O’Donnell Jr. Brain Institute.Subscribe to the Alzheimer's Reading RoomEmail:A DNA vaccine tested in mice reduces accumulation of both types of toxic proteins associated with Alzheimer ’s disease, according to research that scientists say may pave the way to a clinical trial.The research published inAlzheimer ’s Research and Therapy demonstrates how a vaccine containing DNA coding for a segment of beta-amyloid also reduces tau in mice modeled to have Alzheimer ’s disease. In addition, the vaccine elicits a different immune response that may be safe for humans. Two previous studies from Dr. Rosenberg ’s lab showed similar immune responses in rabbits and monkeys.How to Test Your Memory for Alzheimer's and Dementia (5 Best Tests)The vaccine is on a shortlist of promising antibody treatments aimed at protecting against both types of proteinsthat kill brain cells as they spread in deadly plaques and tangles on the brains of Alzheimer ’s disease patients.Although earlier research est...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's research alzheimers Beta Amyloid dementia dna health memory memory loss science tau vaccine Source Type: blogs