Colonic MicroRNA Profiles, Identified by a Deep Learning Algorithm, That Predict Responses to Therapy of Patients With Acute Severe Ulcerative Colitis

Acute severe ulcerative colitis (ASUC) is a life-threatening condition managed with intravenous steroids followed by infliximab, cyclosporine, or colectomy (for patients with steroid resistance). There are no biomarkers to identify patients most likely to respond to therapy; ineffective medical treatment can delay colectomy and increase morbidity and mortality. We aimed to identify biomarkers of response to medical therapy for patients with ASUC.

Source: Clinical Gastroenterology and Hepatology - September 14, 2018 Category: Gastroenterology Authors: Ian Morilla, Mathieu Uzzan, David Laharie, Dominique Cazals-Hatem, Quentin Denost, Fanny Daniel, Genevieve Belleannee, Yoram Bouhnik, Gilles Wainrib, Yves Panis, Eric Ogier-Denis, Xavier Treton Source Type: research