Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma

ConclusionsOur results indicate the involvement of crucial oncogenic driver pathways, highlighting cell cycle and ribosomal pathways in the aetiology of ADPA. Suggested tumour ‐overexpression ofFGFR2 raises the hope that targeting the FGF/FGFR axis might be a promising treatment for ADPA and probably for the overall group of sweat gland carcinomas.This article is protected by copyright. All rights reserved.

Source: British Journal of Dermatology - November 25, 2018 Category: Dermatology Authors: H.M. Surowy, A.K. Giesen, J. Otte, R. B üttner, D. Falkenstein, H. Friedl, F. Meier, P. Petzsch, T. Wachtmeister, D. Westphal, D. Wieczorek, W. Wruck, J. Adjaye, A. Rütten, S. Redler Tags: Original Article Source Type: research