Influence of Naftopidil on Plasma Monoamine Levels and Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia
ConclusionsThe modulation of plasma adrenaline and serotonin levels by naftopidil in patients with increased sympathetic activity contributed to improvement of LUTS associated with BPH, in addition to its antagonistic effects of α1D/A‐adrenergic receptor on the detrusor and prostatic urethral smooth muscle, the urothelium, and the central nervous system.
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Tom Marcelissen, Kevin Rademakers
Publication date: Available online 14 November 2019Source: Life SciencesAuthor(s): Panagiotis Lekkas, Marianthi Kontonika, Evgenia S. Georgiou, Vassileios La Rocca, Eleni-Taxiarchia Mouchtouri, Iordanis Mourouzis, Constantinos Pantos, Theofilos M. KolettisAbstractAimsEndothelin has been implicated in various processes in the brain, including the modulation of sympathetic responses. The present study examined the pathophysiologic role of brain endothelin-receptors in the setting of acute myocardial infarction, characterized by high incidence of ventricular tachyarrhythmias.Main methodsWe investigated the effects of intracer...
ConclusionsTortuosity of pelvic arteries was more frequent in older patients and predicted worse technical outcomes of PAE. PA origin from obturator artery was associated with lower DAP and fluoroscopy time, especially compared with PA origin from superior vesical artery. Interventionalist experience showed significant influence on technical outcome.
In conclusion, limited evidence shows that routine urodynamics prior to non-surgical management of UI or surgical management of SUI is not associated with improved treatment outcomes, when compared to clinical evaluation only. Well-designed clinical trials are needed to evaluate the clinical and cost-effectiveness of routine urodynamics prior to surgical management of SUI and OAB.
In conclusion, our results indicate that PBMT in the parameters selected, attenuated the dystrophic phenotype ofmdx mice, improving skeletal muscle regeneration; reducing the oxidative stress and inflammatory process; and up ‐regulating the angiogenic marker.
Authors: Roshmi RR, Yokota T Abstract Duchenne muscular dystrophy is the most common lethal X-linked genetic disorder, characterized by progressive muscle loss, with cardiac and respiratory complications. It is caused by a lack of dystrophin protein due to mutations in the DMD gene, which can disrupt the reading frame of the dystrophin primary transcript. Antisense oligonucleotides such as phosphorodiamidate morpholino oligomers (PMOs) can induce exon skipping during pre-mRNA splicing and restore the reading frame of the DMD primary transcript. The resulting dystrophin protein is internally deleted but partially fu...
Authors: Oliveira-Ferreira C, Leuzinger-Dias M, Tavares-Ferreira J, Silva SE, Brandão E, Falcão-Reis F, Rocha-Sousa A PMID: 31718366 [PubMed - as supplied by publisher]
CONCLUSION: Since the hypothalamus represents the link through which the immune functions may influence the psychic functions and vice versa, the psychic functions may influence the immune functions, the cerebellum, controlling several regions of the hypothalamus, could be considered as a primary player in the regulation of the multiple functional interactions postulated by the psychoneuroendocrinoimmunology. PMID: 31729296 [PubMed - as supplied by publisher]
The use of preoperative urodynamics as a standard investigation for urinary incontinence (UI) has long been a subject of debate, with a lack of robust evidence to demonstrate improved patients ’ outcomes. We aim to compare the clinical and cost effectiveness of urodynamics versus office clinical evaluation only, prior to the treatment of UI. We conducted three linked systematic reviews and meta-analyses of randomised controlled trials (RCTs) comparing urodynamics assessment versus clini cal evaluation only in women prior to 1) non-surgical treatment of UI, 2a) surgical treatment of stress urinary incontinence (SUI) a...
ConclusionsMirabegron efficacy, safety, and tolerability over 12 wk were confirmed in patients aged ≥65 yr with OAB and incontinence.Patient summaryWe examined the effect of mirabegron compared with placebo in people aged 65 yr or older with overactive bladder and incontinence. Mirabegron improved the symptoms of overactive bladder compared with placebo. Side effects were similar to those already known for mirabegron.