Sevoflurane anesthesia deteriorates pulmonary surfactant promoting alveolar collapse in male Sprague–Dawley rats

In conclusion, the observed changes in surfactant composition and viscosity properties suggest a direct effect of sevoflurane on surfactant function, a factor potentially involved in anesthetic-induced alterations in lung mechanics.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research