Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma

In conclusion, JNJ-40929837 demonstrated target engagement in blood and sputum. No significant impact in response to allergen inhalation was observed with JNJ-40929837 versus placebo. Registration This study is registered at ClinicalTrials.gov: NCT01241422.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Condition:   Asthma Interventions:   Drug: AZD8154 nebulizer suspension, 20 mg/mL;   Drug: Placebo Sponsors:   AstraZeneca;   Parexel Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Allergy;   Asthma;   Food Allergy;   Allergic Sensitisation;   Atopic Dermatitis Intervention:   Sponsors:   Pontificia Universidad Catolica de Chile;   University of Chile;   Comisión Nacional de Investigación Científica y Tecnológica Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Eosinophilic Asthma;   Chronic Sinusitis;   Eosinophilic Rhinitis Intervention:   Sponsor:   University Hospital, Lille Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 4 December 2019Source: Joint Bone SpineAuthor(s): Chang-Fu Kuo, Patricia B. Burns, Jung-Sheng Chen, Lu Wang, Kevin C. ChungAbstractObjective: The purpose of the study is to investigate the risk of preventable hospitalization among patients with rheumatoid arthritis (RA).Methods: We identified 11,852 incident RA patients and 59,260 age-, sex-, and index year-matched controls from the Taiwan National Health Insurance Database. Index date was the RA diagnosis date for cases, which was assigned to their matched controls. The odds ratios (OR) of preventable hospitalizations between RA patients...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Chiesi Farmaceutici, an Italian drug-making company, is working on filling inhalers with a new type of propellant which is better for the environment than current gases.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Saenza De San Pedro A, Lopes MP, Sokolova A, Abreu C, Lopes C Abstract Summary: Atopic Dermatitis (AD) affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was grante...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
npj Primary Care Respiratory Medicine, Published online: 05 December 2019; doi:10.1038/s41533-019-0156-4A multinational observational study identifying primary care patients at risk of overestimation of asthma control
Source: npj Primary Care Respiratory Medicine - Category: Primary Care Authors: Source Type: research
CONCLUSION: JIA appears to be associated with an increased risk of T1D compared to asthma and healthy children. PMID: 31787600 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Authors: Magrone T, Magrone M, Jirillo E Abstract BACKGROUNDS: Mast cells (MCs) bear many receptors which allow them to respond to a variety of exogenous and endogenous stimuli. However, MC function is dual since they can initiate pathological events or protect the host against infectious challenges. Involvement of mast cells in various disease: The role of MCs in disease will be analyzed in a broad sense, describing cellular and molecular mechanisms related to their involvement in auto-inflammatory diseases, asthma, autoimmune diseases and cancer. On the other hand, their protective role in the course of bacterial...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Condition:   Asthma Intervention:   Drug: Foster Sponsors:   Far Eastern Memorial Hospital;   Orient Europharma Co., Ltd. Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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