Compare the efficacy of inhaled budesonide and systemic methylprednisolone on systemic inflammation of AECOPD

Conclusions Inhaled budesonide and systemic methylprednisolone have the same effects on systemic inflammation of AECOPD. Inhaled corticosteroid alone could instead systemic corticosteroid in AECOPD treatment.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Conclusion and Future Directions Above we reviewed a limited set of network medicine philosophies that seek to integrate biomedical big data to uncover meaningful biology. Network medicine approaches provide customized and optimized ways to leverage biomedical data. The choice of the appropriate network method is largely dictated by the underlying biological inquiry, hypotheses, study design, and available data. Although this review is not meant to be exhaustive, our intent was to give a essence of how biomedical data requires a nuanced approach when selecting network analyses and provide a resource for both network scien...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion: LABA/LAMA therapy in comparison with LABA/IKS therapy was superior in improvement pulmonary function, health status, quality of sleep, decreasing in morning symptoms and frequency of exacerbations.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
Rationale: This combination of fluticasone propionate (FP) and the long-acting β2-agonist salmeterol (Salm) can control the symptoms of asthma and COPD better than FP or Salm on their own and better than the combination of inhaled corticosteroids plus montelukast. FP/Salm has been shown to control symptoms of asthma and COPD better than a double dose of inhaled steroids. The patient in our report had a history of COPD, and suffered relapse of RP when given only steroids. It is possible that COPD history helps explain this patient's more difficult treatment course. Therefore, this combination may be more effective th...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In conclusion, breathlessness was cited in these interviews as the COPD symptom with the greatest impact on participants' daily functioning, activities and self-care. The findings provided significant additional knowledge to the SLS COPD study findings. PMID: 29247229 [PubMed - in process]
Source: Primary Care - Category: Primary Care Authors: Tags: NPJ Prim Care Respir Med Source Type: research
We have recently read some criticisms raised from Sforza et al. [1] in Sleep Medicine about our paper entitled "Obstructive sleep apnoea as a risk factor for osteopenia and osteoporosis in the male population" published in the European Respiratory Journal last March [2]. In the latter, we reported the significant reduction of the bone mineral density in a large population of male severe obstructive sleep apnoea (OSA) patients (apnoea–hypopnoea index>30 events per h) compared to a population of age- and body mass index (BMI)-matched controls [2]. Since we published our report as a research letter we could...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep medicine Original Articles: Correspondence Source Type: research
Objective: Determine the effect of the first corticosteroid dose on success of Non-invasive ventilation (NIV) in COPD exacerbationsMethods: Observational, retrospective study. January-2013/June-2015. Patients with ≥ 1,5 mg/kg/day of methylprednisolone in the first 24 hours, were compared to those treated with lower doses. Baseline characteristics, pulmonary function, obstructive sleep apnea, and arterial blood gases (ABG) at admission/discharge were retrieved. NIV failure (No pH correction in 72 hours, need of invasive ventilation, or death). Adverse effects were collected. Quantitative variables with normal distributio...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 2.2 Noninvasive Ventilatory Support Source Type: research
ConclusionsPatients with CRS often present with uncontrolled asthma, and ESS improves both miniAQLQ and ACT. Approximately half of patients with uncontrolled asthma improve after ESS, yet there are few CRS‐specific factors associated with asthma QOL or control or ESS outcomes.This article is protected by copyright. All rights reserved.
Source: Allergy - Category: Allergy & Immunology Authors: Tags: Original Article: Airway Diseases Source Type: research
Introduction: Idiopathic pulmonary fibrosis (IPF) is a lethal disease affecting older individuals.Recognition and treatment of non-pulmonary comorbidities may improve the quality of life of these patients.Methods: Data from the European IPF Registry were used. The patients and physicians questionnaire from 386 patients with IPF, 60 with hypersensitivity pneumonitis (HP), 85 with ILD in the frame of a collagenosis, 70 patients with COPD and 85 with lung cancer were analysed.Results: The mean age of IPF patients (71% males) was 66,84± 11,22 years. The mean % predicted of FVC was 65,75 ± 23,59 and of DLCO 40,30 ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 1.5 Diffuse Parenchymal Lung Disease Source Type: research
Conclusion: Overlap syndromes are more likely have respiratory failure compared to only COPD during AECOPD. AECOPD have a high prevalence of OSAS. Overlap syndrome have significantly higher likelihood of obesity and metabolic syndrome compared to only COPD.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
This article describes a case involving a 52-year-old woman with idiopathic scoliosis who was referred to the authors? centre for an unresolving pneumonia. Implementation of a targeted screening program to detect airflow obstruction suggestive of chronic obstructive pulmonary disease within a presurgical screening clinicChronic obstructive pulmonary disease (COPD) affects a significant proportion of the population =40 years of age, and is a leading cause of hospitalization, emergency department visits and mortality. Unfortunately, however, COPD appears to be underdiagnosed and is poorly controlled in many individuals. Ther...
Source: Canadian Respiratory Journal - Category: Respiratory Medicine Source Type: research
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