Bilateral Retroperitoneal Hibernoma Identified by I-MIBG SPECT/CT in a Patient With Single Pheochromocytoma

Publication date: November 2018Source: Cirugía Española (English Edition), Volume 96, Issue 9Author(s): Dennis César Lévano-Linares, Jaime Ruiz-Tovar, Alejandro García Muñoz-Najar, Verónica Familiar, Manuel Durán Poveda
Source: Cirugia Espanola - Category: Surgery Source Type: research

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Publication date: Available online 8 September 2019Source: Journal of Cardiology CasesAuthor(s): Hiroaki Kawano, Takao Ando, Yohei Shida, Daisuke Niino, Koji Maemura, Kioko KawaiAbstractA 44-year-old Japanese man was referred to our hospital for the evaluation of paroxysmal hypertension. 123I-metaiodobenzylguanidine (MIBG) single-photon emission computed tomography (SPECT) revealed specific uptake in the left adrenal gland in addition to high levels of serum and urinary catecholamines although computed tomography and magnetic resonance imaging were not able to detect a definite adrenal mass. Left adrenalectomy was performe...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Opinion statementNeuroendocrine tumors (NETs) are relatively rare, with 12,000 –15,000 new cases diagnosed annually in the USA. Although NETs are a diverse group of neoplasms, they share common molecular targets that can be exploited using nuclear medicine techniques for both imaging and therapy. NETs have traditionally been imaged with SPECT imaging using111In-labeled octreotide analogs to detect neoplasms with somatostatin receptors. In addition, certain NETs (pheochromocytomas, paragangliomas, and neuroblastomas) are also effectively imaged using123I- or131I-labeled metaiodobenzylguanidine (MIBG), an analog of gua...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionSince the European Association of Nuclear Medicine 2012 guidelines, the excellent results obtained with gallium-68 (68Ga)-labelled somatostatin analogues (SSAs) in recent years have simplified the imaging approach for PPGL patients that can also be used for selecting patients for peptide receptor radionuclide therapy as a potential alternative or complement to the traditional theranostic approach with iodine-123 (123I)/iodine-131 (131I)-labelled meta-iodobenzylguanidine. Genomic characterisation of subgroups with differing risk of lesion development and subsequent metastatic spread is refining the use of molecula...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conclusions: 68Ga-DOTA-NOC PET/CT shows higher sensitivity in the detection of bone metastasis and lymphadenopathy in PHEOs/PGLs, which has great merits for staging and risk stratification of PHEOs/PGLs. PRRT has good response especially in symptom release and improvement of living quality, and is tolerable with no evident hematological events and renal toxicity. Furthermore, present study will pave the way for SSA based theranostics on PHEOs/PGLs. Keywords: Pheochromocytomas, Paragangliomas, 68Ga-DOTA-NOC,131I-MIBG, Somatostatin Receptor Abbreviations: PHEO: Pheochromocytoma; PGL: Paraganglioma; MIBG: Metaiodobenzylguanid...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrinology (Clinical Therapy) Posters Source Type: research
AbstractPheochromocytomas (PCCs) and paragangliomas (PGLs) are rare, heterogeneous neuroendocrine neoplasms of the autonomous nervous system of chromaffin cell origin that may arise within the adrenal medulla (PCCs) or the sympathetic and parasympathetic paraganglia (PGLs). Currently referred to by the umbrella term pheochromocytomas –paragangliomas (PPGLs), these distinct tumors are characterized by specific histopathology as well as biological and clinical profiles. PPGLs may occur as part of hereditary syndromes (40% of cases) or as sporadic tumors. Currently, there are 12 different hereditary syndromes with chara...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Publication date: Available online 10 November 2018Source: Cirugía Española (English Edition)Author(s): Dennis César Lévano-Linares, Jaime Ruiz-Tovar, Alejandro García Muñoz-Najar, Verónica Familiar, Manuel Durán Poveda
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 4 April 2018Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): Alexander Stephan Kroiss, Christian Uprimny, Renate Pichler, Rudolf Wolfgang Gasser, Irene Johanna VirgoliniAbstractPheochromocytoma (PHEO) is rare and belongs to the group of neuroendocrine tumours (NETs). These tumours can be found anywhere from the neck to the pelvis associated with sympathetic ganglia. Morphological imaging, for example CT, provides excellent anatomical detail and high sensitivity but lacks specificity as difficulties may occur when distinguishing between tum...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Conclusions: LMI1195, a novel F-18-labeled PET-tracer, is highly effective in detecting tumors of the adrenal medulla or the sympathetic trunk. High uptake in lesions and superb image quality promote its use as alternative to MIBG. Further potential applications (e.g. assessment of the sympathetic innervation of the heart) should be evaluated.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: First-in-Human & amp; New Human Applications Source Type: research
Conclusion [Tc-99m]-TOC imaging should be used as an initial imaging approach in detection and follow-up of VHL manifestations, screening of asymptomatic gene carriers, and in diagnosis of pheochromocytoma, PNET, CNS hemangioblastomas and RCC.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine/Neuroendocrine Posters Source Type: research
Publication date: Available online 4 April 2018 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Author(s): Alexander Stephan Kroiss, Christian Uprimny, Renate Pichler, Rudolf Wolfgang Gasser, Irene Johanna Virgolini Pheochromocytoma (PHEO) is rare and belongs to the group of neuroendocrine tumours (NETs). These tumours can be found anywhere from the neck to the pelvis associated with sympathetic ganglia. Morphological imaging, for example CT, provides excellent anatomical detail and high sensitivity but lacks specificity as difficulties may occur when distinguishing between tumours ...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
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