Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats.

Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats. Neuropharmacology. 2018 Nov 21;: Authors: Tosic J, Stanojevic Z, Vidicevic S, Isakovic A, Ciric D, Martinovic T, Kravic-Stevovic T, Bumbasirevic V, Paunovic V, Jovanovic S, Todorovic-Markovic B, Markovic Z, Danko M, Micusik M, Spitalsky Z, Trajkovic V Abstract We investigated the therapeutic capacity of nano-sized graphene sheets, called graphene quantum dots (GQD), in experimental autoimmune encephalomyelitis (EAE), an animal model of immune-mediated central nervous system (CNS) damage. Intraperitoneally administered GQD (10 mg/kg/day) accumulated in the lymph node and CNS cells of Dark Agouti rats in which EAE was induced by immunization with spinal cord homogenate in complete Freund's adjuvant. GQD significantly reduced clinical signs of EAE when applied throughout the course of the disease (day 0-32), while the protection was less pronounced if the treatment was limited to the induction (day 0-7 post-immunization) or effector (from day 8 onwards) phase of the disease. GQD treatment diminished immune infiltration, demyelination, axonal damage, and apoptotic death in the CNS of EAE animals. GQD also reduced the numbers of interferon (IFN)-γ-expressing T helper (Th)1 cells, as well as the expression of Th1 transcription factor T-bet and proinflammatory cytokines tumor necrosis factor, interleukin-1, and granulocyte-macrophage colony-stimulating factor in t...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research