Identifying the need to refine the potential patient risk factors for niraparib-induced thrombocytopenia.

CONCLUSION: The data suggests that renal insufficiency and hypoalbuminemia may be associated with the development of niraparib-induced thrombocytopenia. Moreover, the preliminary in vitro studies also demonstrated a concentration-dependent relationship between niraparib and direct toxicity to platelets.
PMID: 30466807 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - November 19, 2018 Category: Cancer & Oncology Authors: Smith JA, Le T, Martin GA, Gaikwad A, Sun CH, Nugent EK, Lucci JA Tags: Gynecol Oncol Source Type: research