Beta1-adrenergic receptor antibodies in children with dilated cardiomyopathy.

Beta1-adrenergic receptor antibodies in children with dilated cardiomyopathy. Front Biosci (Elite Ed). 2019 Jan 01;11:102-108 Authors: Camino M, Morales MD Abstract Autoantibodies to beta-1 adrenergic receptor have been reported in adult patients with dilated cardiomyopathy (DCM). Removal of these antibodies has a positive hemodynamic effect. Our aim was to investigate whether these antibodies are present in children with DCM and explore the potential hemodynamic benefit of immunoadsorption (IA). Seventeen children with DCM  were tested for these antibodies. The etiology of DCM was genetic (n=5), myocarditis (n=4), DCM and congenital heart block (n=3), DCM associated to maternal lupus (n=1), DCM and Wolff Parkinson White Syndrome (n=1), and idiopathic (n=3). All patients evidenced ventricular dysfunction. Antibody testing was positive in 8 patients, 7  received IA.  Three patients with high titers had a poor clinical outcome and needed transplantation. Two patients with low titers exhibited a full recovery of heart function. One patient with multiple myocarditis episodes was treated with immunoglobulin IgG and IA ; after 5 years this patient presented a LVEF of 40 percent. Beta-1 adrenergic receptors autoantibodies are present in children with DCM. Immunoadsorption therapy may help improve heart failure in this context. PMID: 30468641 [PubMed - in process]
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

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CONCLUSIONS: This is the first report on discordant lymphoma consisting of mantle cell lymphoma and angioimmunoblastic T cell lymphoma. There seems to be no relation these two different kinds of lymphoma, and EBV infection might prompt the development of angioimmunoblastic T cell lymphoma after transplantation. Rash is a common clinical manifestation when T cell lymphoma develops after treatment for MCL. PMID: 32055275 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
This study investigates the prognostic impact of the expression of hypoxia inducible factor (HIF)-1α and Toll-like receptor (TLR) 3 detected by immunohistochemistry in oral squamous cell carcinoma (OSCC). The study also evaluates the treatment outcome by inhibition of the HIF-1α and TLR 3 pathway (nuclear factor [NF]-κB) in an OSCC transplantation model in nude mice. Statistical analysis of immunohistochemical results with clinical findings that included overall survival outcomes was performed for 90 OSCC patients. Forty nude mice were divided into four groups (control; inhibition of HIF-1α; inhibit...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
Publication date: Available online 14 February 2020Source: American Heart JournalAuthor(s): Bao-Oanh Nguyen, Michiel Rienstra, Anne H. Hobbelt, Jan G.P. Tijssen, Marcelle D. Smit, Robert G. Tieleman, Bastiaan Geelhoed, Dirk J. Van Veldhuisen, Harry J.G.M. Crijns, Isabelle C. Van Gelder, RACE 3 InvestigatorsAbstractAtrial fibrillation (AF) is a progressive disease, and maintenance of sinus rhythm is cumbersome. In this analysis of the Routine versus Aggressive risk factor driven upstream rhythm Control for prevention of Early atrial fibrillation in heart failure (RACE 3) trial we aimed to determine whether optimal treatment...
Source: American Heart Journal - Category: Cardiology Source Type: research
This study prospectively evaluated outcomes of a new approach for these lungs in our lung transplant program.MethodsFrom 2/2016—12/2018, 336 lung transplants were performed at Cleveland Clinic. Of these, 58 met criteria for our aggressive approach to donors with P/F ratio
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Hypertonic saline (HS) appears to be safe and well tolerated as an adjuvant to loop diuretics in refractory acute decompensated heart failure (ADHF), according to a retrospective study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Cardiology News Source Type: news
The disease, which normally affects people later in life, forced Ryan to make a "scary" decision.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Publication date: Available online 14 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): M. Trum, S. Wagner, L.S. Maier, J. MustrophAbstractEmpagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been shown to reduce mortality and hospitalization for heart failure in diabetic patients in the EMPA-REG-OUTCOME trial (Zinman et al., 2015). Surprisingly, dapagliflozin, another SGLT2 inhibitor, exerted comparable effects on clinical endpoints even in the absence of diabetes mellitus (DAPA-HF trial) McMurray et al. (2019). There is a myriad of suggested under...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Conclusion: We proposed that the crescents were not uncommon and had important clinical significance in lupus nephritis. The cutoff point of crescents as prognosticator might be nearly 7.39%. PMID: 32054387 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Type 2 diabetes mellitus (T2DM) is a considerable risk factor of cardiovascular disease, heart failure, chronic kidney disease, and mortality [1 –4]. Diabetes caused 4 million deaths in 2017, with more than 0.84 million in China [5]. The prevalence of T2DM is increasing in many countries with the speeding up of urbanization and change in lifestyle. The International Diabetes Federation estimated that approximately 425 million adults (20– 79 years) were living with diabetes in 2017, 79% were from low- and middle-income countries, and this number would rise to 629 million by 2045 [5].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Publication date: Available online 14 February 2020Source: Journal of Electroanalytical ChemistryAuthor(s): Huan Liu, Yan Cheng, Yingying Chen, Hongbo Xiao, Yuyun Sui, Qingji Xie, Rushi Liu, Xiaoping YangAbstractThe rapid and sensitive detection of heart failure biomarker galectin-3 (Gal-3) is of great value in the prevention, diagnosis, treatment, and prognosis-evaluation of heart failure. Here, a high-performance dual-signal sandwich-type electrochemical immunosensor for Gal-3 was constructed by the covalent immobilization of the first antibody on electroreduced carboxyl graphene and the adsorption immobilization of the ...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
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