Curcumin prevents cigarette smoke extract induced cognitive impairment.

Curcumin prevents cigarette smoke extract induced cognitive impairment. Front Biosci (Elite Ed). 2019 Jan 01;11:109-120 Authors: Muthuraman A, Thilagavathi L, Jabeen S, Ravishankar SB, Ahmed SS, George T, Rishitha N, Paramakrishnan N Abstract Curcumin is a major phytochemical constituent in Curcuma longa, an herbaceous perennial plant of Zingiberaceae family, which exhibits anti-oxidant, anti-inflammatory and immunomodulatory properties. Here, we studied the therapeutic action of curcumin against CSE induced cognitive impairment in zebrafish. Montelukast (20 mg/kg), a cysteinyl-leukotriene receptor blocker was used as a reference drug. CSE exposure induced biochemical changes revealed that raise the brain acetylcholinesterase activity and lipid peroxidative products; and decrease the reduced glutathione levels in brain samples. Curcumin also protected against CSE induced neurocognitive impairment. These data suggest that curcumin can serve as a phytochemical constituent against CSE induced neurocognitive impairment. PMID: 30468642 [PubMed - in process]
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research