Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism.

The objective of the present study was to investigate the effects of troxerutin (TX) on Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. L-NAME (40mg/kg body weight (bw)) administration caused a sustained increase in systolic blood pressure (SBP), levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), tissue lipids (liver and kidney) such as total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), and significant decrease in the activities of enzymatic antioxidants, phospholipids (PL) and levels of non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E. To assess the toxicity if any of TX treatment, hepatic and renal function markers were measured. TX supplementation throughout the experimental period significantly brings back all the above parameters. Among the three doses (25, 50, and 100 mg/kg) of TX, 100 mg/kg dosage exerts optimum protection against L-Name induced hypertension. These results suggest that TX has enough potential to attenuate hypertension, oxidative stress and dyslipidemia in L-NAME induced hypertensive rats. PMID: 30468643 [PubMed - in process]
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

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Conclusion: Evolocumab may have a beneficial effect on renal involvement in patients with CCE. PMID: 32046605 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
#DYK African American women often have more heart attack risk factors than white women, such as high blood pressure, high cholesterol &diabetes? Get tips on managing these conditions &making #HeartHealthy decisions: … via @FDAWomen
Source: Food and Drug Adminstration (FDA): CDRHNew - Category: Medical Devices Authors: Source Type: news
(Natural News) Heart disease and cerebrovascular diseases (e.g., stroke) are the leading causes of death in western countries. These diseases are caused by several factors, such as hypertension, high blood cholesterol, diabetes mellitus, smoking and obesity. However, recent studies have found that there is another unexpected contributor to the development of atherosclerosis and atherothrombosis (blood clot...
Source: - Category: Consumer Health News Source Type: news
AbstractAimTo analyze the socioeconomic conditions and health status of older persons living in 11 Quilombola communities (settlements originally created by escaped slaves) in the Baixada Maranhense region, Brazil.Subjects and methodsA cross-sectional household survey of the socioeconomic status, sanitary conditions, health behavior, and self-reported morbidities was conducted with 208 older persons. Fisher ’s exact test and the chi-squared test were performed (α = 5%) to determine statistically significant gender and age differences in the prevalence of morbidities and multimorbidities (≥ 2 an...
Source: Journal of Public Health - Category: Health Management Source Type: research
AbstractPurpose of ReviewTo review the rationale and biological plausibility and discuss the current research on novel interventions for the prevention of preeclampsia.Recent FindingsPreeclampsia affects up to 8% of pregnancies worldwide and remains a major cause of maternal and neonatal morbidity and mortality. Multiple medications have been investigated or repurposed as potential effective interventions for preeclampsia prevention. Aspirin is currently the only drug for which there is some evidence of benefit for preeclampsia prevention, and its use is recommended by professional societies for pregnancies at risk. Statin...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
Grants to organizations in Iowa to promote the adoption and use of electronic health records and health information technology to improve provider outcomes and patient health outcomes related to identification of individuals with undiagnosed hypertension and undiagnosed high cholesterol and management of adults aged 18-85. Geographic coverage: Iowa -- Iowa Department of Public Health
Source: Funding opportunities via the Rural Health Information Hub - Category: American Health Source Type: funding
In conclusion, SBP was positively correlated with age, but DBP did not change significantly with age. The correlation of BP and HDL-C depending on age showed that SBP gradually increased and HDL-C decreased with an increase in age. The percentage of HDL-C in TC was more significantly associated with a change in SBP and DBP in both genders.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
No abstract available
Source: Journal of Hypertension - Category: Cardiology Tags: EDITORIAL COMMENTARIES Source Type: research
Objective: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men. Methods: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18–95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 ±...
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research
Objective: Statin therapy was associated with lower blood pressure (BP) in some but not all studies. We evaluated the association between statin therapy and ambulatory BP in a large hypertensive population using ‘propensity score matching’. Methods: Retrospective observational study on 1827 consecutive essential hypertensive patients evaluated with 24-h ambulatory BP monitoring. Antihypertensive treatment intensity (ATI) was calculated to compare different drug associations. We used a propensity score matching to compare two equally-sized cohorts of patients with similar characteristics according to statin...
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research
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