The impact of genetic variants in IL1R2 on cervical cancer risk among Uygur females from China: A case –control study

This study showed evidence for IL1R2 polymorphisms in correlation to cervical cancer risk in Uygur females. Our research could provide bases for tumorigenesis genetic research in Ch inese minorities. AbstractBackgroundDisordered inflammation and immune response is an acknowledged risk factor for cervical cancer development. Interleukin ‐1 receptor type 2 (IL1R2) is a decoy receptor for IL‐1 cytokines and involved in host inflammatory and immune progression which could lead to the lesion and neoplasia of cervix. In this study, we aimed to evaluate the relationships betweenIL1R2 polymorphisms and cervical cancer risk in Uygur females from China.MethodsIn this case –control study, genotypes of six selected variants (rs11674595, rs4851527, rs719250, rs3218896, rs3218977, and rs2072472) distributed inIL1R2 were detected among 247 cervical cancer patients and 286 healthy controls with the usage of an Agena MassARRY method. Furthermore, Genetic models and haplotype analyses were conducted to estimate the associations ofIL1R2 polymorphisms with cervical cancer risk.ResultsAfter statistical analyses, rs719250 (odd ratio [OR]  = 1.436, 95% confidence interval [95% CI] = 1.079–1.911,p = 0.013) and rs3218896 (OR = 1.552, 95% CI = 1.080–2.229,p = 0.017) showed obvious evidence in correlation to cervical cancer susceptibility owing to the surviving significant differences between cases and controls in allele ...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Source: WebMD Health - Category: Consumer Health News Source Type: news
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Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Authors: Pimple SA, Mishra GA Abstract Disparities in the incidence and mortality due to cervical cancer between developed and developing countries continue to persist due to suboptimal health care systems in low- to middle-income countries (LMICs) that are unable to implement organized programs for screening which lack the technical, infrastructure and financial resources for adequate coverage and access to quality assured cervical cancer screening services that further reduce their effectiveness. The challenges in introducing quality cytology screening in LMICs led to the evaluation of alternative screening appro...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
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Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
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Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
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Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
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Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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