Annals of Neurology: Volume 84, Number 5, November 2018

A photomicrograph of HeLa cells expressing amino acids 1 ‐149 of the protein KCTD7 with a mutation (L108M) seen in patients who have progressive myoclonic epilepsy (EPM3) also known as neuronal ceroid lipofuscinosis (CLN14). The mutant protein has an HA tag that has been stained with red fluorescence to localize the protein, revealing red filaments in t he nucleus and in the surrounding cytoplasm. Filament structures are altered by this L108M mutation in the BTB domain of KCTD7. The nucleus of each cell is stained blue. (See Metz et al., pageshttp://dx.doi.org/10.1002/ana.25351766 –780)
Source: Annals of Neurology - Category: Neurology Tags: Cover Image Source Type: research

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To report progress, to identify gaps, and to plan epilepsy surveillance and research activities more effectively, the Centers for Disease Control and Prevention (CDC) Epilepsy Program has summarized findings from selected CDC-supported surveillance and epi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Abstract SUMMARYTaenia solium neurocysticercosis (NCC) is endemic in most of the world and contributes significantly to the burden of epilepsy and other neurological morbidity. Also present in developed countries because of immigration and travel, NCC is one of few diseases targeted for eradication. This paper reviews all aspects of its life cycle (taeniasis, porcine cysticercosis, human cysticercosis), with a focus on recent advances in its diagnosis, management, and control. Diagnosis of taeniasis is limited by poor availability of immunological or molecular assays. Diagnosis of NCC rests on neuroimaging finding...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
Conditions:   Resistant Epilepsy, Drug;   Adolescent Epilepsy;   Children Epilepsy;   Children and Adolescents With Resistant Epilepsies Interventions:   Drug: MGCND00EP1;   Drug: Placebo;   Diagnostic Test: ECG;   Diagnostic Test: EEG;   Diagnostic Test: Blood and urine collection Sponsor:   MGC Pharmaceuticals d.o.o Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
NEUROSURGERY CLINICS OF NORTH AMERICA
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
The notion of paradigm shifts in science was introduced in 1962 by the American physicist and philosopher Thomas Kuhn, describing a set of fundamental changes in the basic concepts, and subsequently, practices, of a scientific discipline. During the last decades, the field of epilepsy surgery in the United States has been through what Kuhn termed a revolutionary period; a period during which a paradigm shift in the way we comprehend and address surgically treatable epilepsies is taking place within our scientific and clinical community.
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
The need to emphasize the network concept arises from the fact that the traditional surgical philosophy in American epilepsy centers has prioritized an electrical-anatomic, focus-oriented approach. In contrast, the stereoelectroencephalography philosophy focuses on using electrophysiology to determine the regions of cortex generating the clinical manifestation of the seizure. Viewing epilepsy surgery as network surgery enables optimal consideration of decisions related to the need for and method of intracranial monitoring, potential role of subcortical structures in seizure organization and propagation, upfront use of comb...
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
This article discusses functional electrical stimulation in adults and children for different functional modalities.
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
Epilepsy is characterized by specific alterations in network organization. The main parameters at the basis of epileptogenic network formation are alterations of cortical thickness, development of pathologic hubs, modification of hub distribution, and white matter alterations. The effect is a reinforcement of brain connectivity in both the epileptogenic zone and the propagation zone. Moreover, the epileptogenic network is characterized by some specific neurophysiologic biomarkers that evidence the tendency of the network itself to shift from an interictal state to an ictal one. The recognition of these features is crucial ...
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
We provide a history and overview of the network approach to epilepsy surgery. Models of the epileptogenic zone (EZ) have evolved considerably over the years with more recent models accounting for the connectivity and network properties of epileptic foci. Next, we describe several examples of network phenotypes of focal epilepsy and how these have the potential to influence surgical decision-making and patient outcome. Future research will provide new insight into how network models of the EZ can determine optimal surgical interventions that improve seizure outcomes and optimize cognitive outcomes.
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
Resective epilepsy surgery relies on accurate preoperative localization of the epileptogenic zone (EZ), so presurgical evaluation is necessary to obtain the most accurate information from clinical, anatomic, and neurophysiologic aspects, with the ultimate goal of performing an individualized surgical treatment. The noninvasive methods of seizure localization are complementary and results must be interpreted in conjunction, in an attempt to compose localization hypotheses of the anatomic location of the EZ. Stereoelectroencephalography is an extraoperative invasive method that is applied in patients with medically refractor...
Source: Neurosurgery Clinics of North America - Category: Neurosurgery Authors: Source Type: research
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