Pulmonary hypertension predicts adverse outcomes in renal patients: a systematic review and Meta ‐Analysis

ABSTRACTIn the general population and in heart disease, pulmonary hypertension (PH) is a strong and independent risk factor for mortality and adverse cardiovascular outcomes. We performed a systematic review and meta ‐analysis of longitudinal cohort studies of individuals with chronic kidney disease (CKD) of any‐stage (also including end‐stage kidney disease –ESKD‐ and kidney transplantation) stratified according to presence/absence of PH.18 eligible studies (10740 participants) were retrieved. PH had an overall pooled prevalence (PP) of 33% (95% CI 28 ‐42) and portended a higher risk of all‐cause mortality (RR 2.08; 1.06‐4.08), cardiovascular mortality (RR 3.77; 2.46‐5.78) and non‐fatal cardiovascular events (RR 1.60; 1.28‐1.99). PH is highly prevalent in CKD and ESKD and may represent a novel factor for mortality and cardiovascular r isk stratification, particularly in selected sub‐categories. Future, high quality research is required to confirm the need for clinical attention on PH in the CKD setting.
Source: Therapeutic Apheresis and Dialysis - Category: Hematology Authors: Tags: Review Source Type: research