Occurence of carbapenemase-producing Enterobacteriaceae in Togo, West Africa

Carbapenems are considered as last-resort therapy for the treatment of infections caused by multidrug resistant (MDR) Gram-negative bacteria. Unfortunately, resistance to carbapenems emerged during the last decade mostly due to the dissemination of carbapenemase-producing Enterobacteriaceae (CPE). In Enterobacteriaceae, carbapenemases belong to (i) Ambler class A enzymes, mostly KPC, (ii) metallo- β-lactamases of NDM-, VIM- and IMP-types and (iii) Amber Class D carbapenem-hydrolysing β-lactamases of OXA-48 familly.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letter to the Editor Source Type: research