Anti-inflammatory, antioxidant and antiproliferative activities from Trichilia silvatica (C.DC).

Anti-inflammatory, antioxidant and antiproliferative activities from Trichilia silvatica (C.DC). Curr Pharm Biotechnol. 2018 Nov 23;: Authors: Da Silva JV, Dos Santos RC, Júnior PCO, Pederiva MMC, Kassuya CAL, Cardoso CAL, Pereira ZV, Ruiz ALTG, Foglio MA, De Carvalho JE, Formagio ASN Abstract The aim of this research was to investigate the anti-inflammatory, antiproliferative and antioxidant activities of the leaves (MEL-TS) and bark (MEB-TS) from T. silvatica. We evaluated the concentrations of phenolic compounds, condensed tannins, flavonoids, flavonols and HPLC/PDA analysis. MEL-TS and MEB-TS were analysed by LC-PDA, and the results revealed the presence of caffeic acid in both extracts. It showed high total phenolics concentrations (270.8 ± 17.10 mg GAE/ g extract and 278.8 ± 25.13 mg GAE/g extract, respectively), and content of flavonoids in MEL-TS (209.30 ± 2.91 mg QE/g extract). In the antioxidant tests, MEL-TS and MEB-TL exhibited moderate scavenging activities with IC50 values ≤ 35.32 μg/mL in lipoperoxidation. Both extracts (30-300 mg/kg) inhibited oedema induced by carrageenan at 2 h and 4 h after carrageenan induction and inhibited leukocyte migration at 6 h post administration. MEL-TS and MEB-TL (100 and 300 mg/kg) did not impact zymosan-induced arthritis in the treated animals. Finally, MEL-TS were particularly effective against VERO and PC-3 cell line resulting in GI50 ≤ 0.22 μg/mL. The results indicated tha...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research