SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field.

In this study the RBE for the CHO-K1 cell line in a passively delivered clinical proton spread out Bragg peak (SOBP) is determined both in vitro and using a silicon-on-insulator (SOI) microdosimetry method paired with the modified microdosimetric kinetic model. The RBE along the central axis of a SOBP with 2 Gy delivered at the middle of the treatment field was found to vary between 1.11-1.98 and the RBE for 10% cell survival between 1.07-1.58 with a 250 kVp x-ray reference radiation and between 1.19-2.34 and 0.95-1.41, respectively, for a Co60 reference. Good agreement was found between RBE values calculated from the SOI-microdosimetry-MKM approach and in vitro. A strong correlation between proton lineal energy and RBE was observed particularly in the distal end and falloff of the SOBP. PMID: 30468682 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30468682?dopt=Abstract

Source: Physics in Medicine and Biology - November 23, 2018 Category: Physics Authors: Debrot E, Tran L, Chartier L, Bolst D, Guatelli S, Vandevoorde C, de Kock E, Beukes P, Symons J, Nieto-Camero J, Prokopovich DA, Chiriotti S, Parisi A, De Saint-Hubert M, Vanhavere F, Slabbert J, Rosenfeld AB Tags: Phys Med Biol Source Type: research