Aedes aegypti vector competence studies: A review.

Aedes aegypti vector competence studies: A review. Infect Genet Evol. 2018 Nov 19;: Authors: Souza-Neto JA, Powell JR, Bonizzoni M Abstract Aedes aegypti is the primary transmitter of the four viruses that have had the greatest impact on human health, the viruses causing yellow fever (YFV), dengue fever (DENV), chikungunya (CHIKV), and Zika fever (ZIKV). Because this mosquito is easy to rear in the laboratory and these viruses grow in laboratory tissue culture cells, many studies have been performed testing the relative competence of different populations of the mosquito to transmit many different strains of viruses. We review here this large literature including studies on the effect of the mosquito microbiota on competence. Because of the heterogeneity of both mosquito populations and virus strains used, as well as methods measuring potential to transmit, it very difficult to perform detailed meta-analysis of the studies. However, a few conclusions can be drawn: (1) Almost no population of Ae. aegypti is 100% naturally refractory to virus infection. Complete susceptibility to infection has been observed for Zika, Dengue and Chikungunya, but not Yellow Fever virus (2) The dose of virus used is directly correlated to the rate of infection. (3) Brazil populations of mosquito are particularly susceptible to DENV-2 infections. (4) The Asian lineage of ZIKV is less infective to Ae. aegypti populations from the American continent than is ...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research