Caryopincaolide M, a rearranged abietane diterpenoid with new skeleton and a new iridoid from Caryopteris incana

AbstractCaryopincaolide M (1), a new rearranged abietane diterpenoid with an unusual pent-4-enoic acid group on a 6/6/5 tricyclic ring system, and 7-epi-8-dehydroxypatriscabrol (3), a new iridoid, together with 17 known compounds, have been isolated from the whole plant ofCaryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1-D and 2-D NMR, IR, and mass spectroscopic data. Compounds1 –5 were evaluated for their inhibitory activities against enzymeα-glucosidase, and the results showed that only1 has moderate inhibitory activity against enzymeα-glucosidase with IC50 at 528.3  ± 12.37 mg/L.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research