Knockdown on aPKC- ι inhibits epithelial-mesenchymal transition, migration and invasion of colorectal cancer cells through Rac1-JNK pathway.

CONCLUSION: Knockdown on aPKC-ι inhibited the EMT, migration and invasion of CRC cells through suppressing of Rac1-JNK pathway. Those findings indicate that aPKC-ι may serve as a novel therapeutic target for CRC.
PMID: 30465755 [PubMed - as supplied by publisher]

Source: Experimental and Molecular Pathology - November 19, 2018 Category: Pathology Authors: Du GS, Qiu Y, Wang WS, Peng K, Zhang ZC, Li XS, Xiao WD, Yang H Tags: Exp Mol Pathol Source Type: research