Differentiation of esophageal pH-impedance characteristics classified by the mucosal integrity marker in human neonates.
CONCLUSIONS: Low BI is associated with prolonged acid exposure, delayed clearance, and greater aerodigestive symptom prevalence, likely associated with inflammation and or increased mucosal permeability. BI > 2000 Ω likely involves little or no inflammation because acid exposure is minimal. Combination of SAP, pH-impedance metrics, and BI along with the clarification of dysmotility mechanisms provides the rationale for personalized anti-reflux therapies as needed.
PMID: 30467343 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Jadcherla SR, Hanandeh N, Hasenstab KA, Nawaz S Tags: Pediatr Res Source Type: research
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