Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review

Ventilator-associated pneumonia (VAP), a subset of hospital-acquired pneumonia (HAP), affects between 17 and 38% of critically-ill patients requiring mechanical ventilation, with an attributable mortality of approximately 13%, which may be reduced by timely recognition and appropriate antibiotic therapy [1 –4]. Current guidelines formulated by the Infectious Diseases Society of America and the American Thoracic Society recommend that while the choice of empiric therapy is influenced by the local hospital epidemiology of health-care associated pathogens, it should also include agents active against S taphylococcus aureus (or methicillin-resistant S.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research